| 1. Round | 10/01/2016 | Club León | - | Santos Laguna | 2:0 | ||||
| 2. Round | 16/01/2016 | CD Veracruz | - | Club León | 1:3 | ||||
| 5. Round | 07/02/2016 | Club León | - | Monarcas Morelia | 1:2 | ||||
| 7. Round | 21/02/2016 | Club León | - | Deportivo Toluca | 5:1 | ||||
| 8. Round | 28/02/2016 | Club León | - | Chiapas FC | 1:3 | ||||
| 9. Round | 05/03/2016 | Club Tijuana | - | Club León | 0:0 | ||||
| 10. Round | 13/03/2016 | Club León | - | Gallos Blancos | 2:0 | ||||
| 13. Round | 11/04/2016 | Pumas UNAM | - | Club León | 1:2 |
Mexico