| 5. Round | 05/02/2017 | Deportivo Guadalajara | - | Santos Laguna | 1:1 | ||||
| 9. Round | 05/03/2017 | Pumas UNAM | - | Santos Laguna | 2:1 | ||||
| 11. Round | 18/03/2017 | Club Tijuana | - | Santos Laguna | 1:1 | ||||
| 12. Round | 03/04/2017 | Santos Laguna | - | Gallos Blancos | 1:0 | ||||
| 13. Round | 10/04/2017 | Santos Laguna | - | CF Pachuca | 1:0 | ||||
| 14. Round | 16/04/2017 | Atlas Guadalajara | - | Santos Laguna | 1:1 | ||||
| 15. Round | 24/04/2017 | Santos Laguna | - | CF América | 2:1 | ||||
| 16. Round | 29/04/2017 | Chiapas FC | - | Santos Laguna | 2:2 |
Mexico