| 1. Round | 22/07/2017 | Lobos BUAP | - | Santos Laguna | 2:2 | ||||
| 2. Round | 31/07/2017 | Santos Laguna | - | UANL Tigres | 1:1 | ||||
| 3. Round | 05/08/2017 | Monarcas Morelia | - | Santos Laguna | 1:1 |  |
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| 4. Round | 14/08/2017 | Santos Laguna | - | CD Veracruz | 2:3 |  |
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| 5. Round | 19/08/2017 | Club Tijuana | - | Santos Laguna | 2:0 | ||||
| 11. Round | 10/11/2017 | CF Monterrey | - | Santos Laguna | 1:1 |
Mexico