| 1. Round | 16/01/2011 | Club Aurora | - | Club San José | 1:1 |  |
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| 2. Round | 23/01/2011 | Club San José | - | Universitario de Sucre | 2:1 | ||||
| 7. Round | 24/02/2011 | La Paz FC | - | Club San José | 1:0 | |
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| 8. Round | 26/02/2011 | Club San José | - | Real Potosí | 2:1 | ||||
| 9. Round | 13/03/2011 | The Strongest | - | Club San José | 0:0 | |
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| 10. Round | 20/03/2011 | Club San José | - | Blooming | 2:1 | |
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| 12. Round | 10/04/2011 | Club San José | - | Club Aurora | 1:0 | ||||
| 13. Round | 17/04/2011 | Universitario de Sucre | - | Club San José | 0:1 | ||||
| 14. Round | 20/04/2011 | Club San José | - | Nacional Potosí | 1:1 | ||||
| 16. Round | 01/05/2011 | Club San José | - | Oriente Petrolero | 1:0 | ||||
| 17. Round | 08/05/2011 | Real Mamoré | - | Club San José | 2:0 | |
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| 19. Round | 15/05/2011 | Real Potosí | - | Club San José | 1:1 | ||||
| 20. Round | 19/05/2011 | Club San José | - | The Strongest | 2:1 | ||||
| 21. Round | 22/05/2011 | Blooming | - | Club San José | 2:1 |
Bolivia