| 1. Round | 17/07/2010 | Sportivo Luqueño | - | Libertad | 1:2 | ||||
| 2. Round | 24/07/2010 | Libertad | - | Tacuary | 3:0 | ||||
| 3. Round | 01/08/2010 | Sport Colombia | - | Libertad | 1:0 | ||||
| 4. Round | 07/08/2010 | Libertad | - | Club Rubio Ñu | 2:1 | ||||
| 5. Round | 15/08/2010 | Club Olimpia | - | Libertad | 0:2 |  |
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| 6. Round | 21/08/2010 | Libertad | - | Sportivo Trinidense | 7:0 | ||||
| 7. Round | 27/08/2010 | Libertad | - | Guaraní | 2:0 | ||||
| 8. Round | 04/09/2010 | Cerro Porteño | - | Libertad | 2:0 | |
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| 9. Round | 11/09/2010 | Libertad | - | Club Nacional | 1:0 |  |
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| 10. Round | 18/09/2010 | Sol de América | - | Libertad | 0:1 | ||||
| 12. Round | 02/10/2010 | Libertad | - | Sportivo Luqueño | 3:1 | ||||
| 13. Round | 09/10/2010 | Tacuary | - | Libertad | 0:1 | ||||
| 14. Round | 16/10/2010 | Libertad | - | Sport Colombia | 4:0 | |
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| 15. Round | 20/10/2010 | Club Rubio Ñu | - | Libertad | 1:3 | |
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| 16. Round | 24/10/2010 | Libertad | - | Club Olimpia | 2:2 | |
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| 17. Round | 30/10/2010 | Sportivo Trinidense | - | Libertad | 1:2 |  |
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| 19. Round | 14/11/2010 | Libertad | - | Cerro Porteño | 2:0 | ||||
| 20. Round | 21/11/2010 | Club Nacional | - | Libertad | 1:0 | ||||
| 21. Round | 28/11/2010 | Libertad | - | Sol de América | 3:0 | |
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| 22. Round | 05/12/2010 | Libertad | - | 3 de Febrero | 5:0 |
Paraguay