| 2. Round | 03/09/2016 | Rampla Juniors | - | Danubio | 2:1 | ||||
| 3. Round | 11/09/2016 | Danubio | - | Villa Española | 1:0 | ||||
| 4. Round | 17/09/2016 | Sud América | - | Danubio | 0:2 |  |
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| 5. Round | 25/09/2016 | Danubio | - | Plaza Colonia | 3:0 | |
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| 6. Round | 01/10/2016 | Racing | - | Danubio | 4:2 | ||||
| 7. Round | 09/10/2016 | Danubio | - | Peñarol | 3:2 | |
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| 8. Round | 16/10/2016 | CA Cerro | - | Danubio | 0:1 | |
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| 9. Round | 23/10/2016 | Danubio | - | River Plate | 2:1 | |
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| 11. Round | 13/11/2016 | Danubio | - | Juventud de Las Piedras | 1:1 | |
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| 12. Round | 20/11/2016 | Danubio | - | Montevideo Wanderers | 0:1 | |
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| 14. Round | 04/12/2016 | Fénix | - | Danubio | 4:1 |
Uruguay