| 1. Round | 18/01/2021 | Plaza Colonia | - | Liverpool | 0:0 |  |
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| 2. Round | 21/01/2021 | Plaza Colonia | - | Progreso | 0:1 | ||||
| 4. Round | 04/02/2021 | Plaza Colonia | - | CA Cerro | 2:1 | |
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| 6. Round | 10/02/2021 | Plaza Colonia | - | Danubio | 3:0 | ||||
| 8. Round | 19/02/2021 | Plaza Colonia | - | Boston River | 3:0 | ||||
| 10. Round | 01/03/2021 | Plaza Colonia | - | Rentistas | 5:0 | |
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| 12. Round | 12/03/2021 | Plaza Colonia | - | Montevideo Wanderers | 3:0 |
Uruguay