| 2. Round | 30/07/2022 | KV Oostende | - | KV Mechelen | 2:1 | ||||
| 3. Round | 06/08/2022 | KV Mechelen | - | Union Saint-Gilloise | 3:0 | ||||
| 4. Round | 13/08/2022 | Cercle Brugge | - | KV Mechelen | 0:0 |  |
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| 5. Round | 21/08/2022 | KV Mechelen | - | KVC Westerlo | 5:4 | ||||
| 6. Round | 27/08/2022 | Sint-Truidense VV | - | KV Mechelen | 3:1 | ||||
| 7. Round | 03/09/2022 | KV Mechelen | - | RFC Seraing | 2:3 | ||||
| 8. Round | 10/09/2022 | KV Kortrijk | - | KV Mechelen | 1:4 | ||||
| 11. Round | 09/10/2022 | KV Mechelen | - | RSC Anderlecht | 1:3 | ||||
| 12. Round | 16/10/2022 | KAA Gent | - | KV Mechelen | 3:0 |
USA
Mexico