2. Round | 15/03/2021 | Real Potosí | - | Club Aurora | 1:1 | ||||
4. Round | 12/04/2021 | Real Potosí | - | San José | 3:0 | ||||
6. Round | 02/05/2021 | Real Potosí | - | Nacional Potosí | 1:2 | ||||
5. Round | 12/05/2021 | Real Santa Cruz | - | Real Potosí | 4:1 | ||||
8. Round | 10/07/2021 | Real Potosí | - | The Strongest | 1:3 | ||||
9. Round | 16/07/2021 | Jorge Wilstermann | - | Real Potosí | 3:1 | ||||
10. Round | 21/07/2021 | Real Potosí | - | Atlético Palmaflor | 1:5 | ||||
11. Round | 24/07/2021 | Always Ready | - | Real Potosí | 2:1 | ||||
12. Round | 30/07/2021 | Real Potosí | - | Royal Pari | 1:3 | ||||
13. Round | 04/08/2021 | Independiente Petrolero | - | Real Potosí | 2:1 | ||||
14. Round | 09/08/2021 | CD Guabirá | - | Real Potosí | 3:0 | ||||
19. Round | 17/09/2021 | San José | - | Real Potosí | 0:0 | ||||
23. Round | 23/10/2021 | The Strongest | - | Real Potosí | 1:0 | ||||
26. Round | 21/11/2021 | Real Potosí | - | Always Ready | 3:2 | ||||
27. Round | 28/11/2021 | Royal Pari | - | Real Potosí | 5:0 | ||||
28. Round | 02/12/2021 | Real Potosí | - | Independiente Petrolero | 0:5 | ||||
29. Round | 05/12/2021 | Real Potosí | - | CD Guabirá | 1:3 | ||||
30. Round | 11/12/2021 | Blooming | - | Real Potosí | 1:0 |