| 4. Round | 07/08/2010 | Libertad | - | Club Rubio Ñu | 2:1 | ||||
| 5. Round | 15/08/2010 | Club Olimpia | - | Libertad | 0:2 | ||||
| 7. Round | 27/08/2010 | Libertad | - | Guaraní | 2:0 |  |
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| 8. Round | 04/09/2010 | Cerro Porteño | - | Libertad | 2:0 | ||||
| 9. Round | 11/09/2010 | Libertad | - | Club Nacional | 1:0 | ||||
| 10. Round | 18/09/2010 | Sol de América | - | Libertad | 0:1 | ||||
| 11. Round | 26/09/2010 | 3 de Febrero | - | Libertad | 2:1 |
Paraguay