| 15. Round | 23/08/2020 | River Plate | - | Libertad | 1:2 |  |
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| 16. Round | 26/08/2020 | San Lorenzo | - | River Plate | 0:0 | ||||
| 17. Round | 29/08/2020 | River Plate | - | Guaraní | 1:0 | ||||
| 18. Round | 04/09/2020 | 12 de Octubre de Itauguá | - | River Plate | 0:1 | ||||
| 19. Round | 12/09/2020 | River Plate | - | Club Olimpia | 0:4 | ||||
| 20. Round | 22/09/2020 | Club Nacional | - | River Plate | 1:2 | ||||
| 21. Round | 27/09/2020 | Cerro Porteño | - | River Plate | 3:1 | ||||
| 22. Round | 03/10/2020 | River Plate | - | Sportivo Luqueño | 0:0 | |
Paraguay