6. Round | 12/03/2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
7. Round | 02/04/2022 | Real Santa Cruz | - | Oriente Petrolero | 2:1 | ||||
8. Round | 09/04/2022 | Atlético Palmaflor | - | Real Santa Cruz | 2:1 | ||||
10. Round | 21/04/2022 | CD Guabirá | - | Real Santa Cruz | 1:0 | ||||
11. Round | 24/04/2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 | ||||
12. Round | 30/04/2022 | The Strongest | - | Real Santa Cruz | 1:1 | ||||
14. Round | 12/05/2022 | Club Aurora | - | Real Santa Cruz | 2:4 | ||||
15. Round | 14/05/2022 | Oriente Petrolero | - | Real Santa Cruz | 1:2 |