| 1. Round | 18/09/2021 | Cañoneros FC | - | Inter de Querétaro | 0:1 |  |
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| 2. Round | 26/09/2021 | Montañeses FC | - | Cañoneros FC | 2:2 | ||||
| 3. Round | 02/10/2021 | Cañoneros FC | - | Leviatán FC | 4:0 | ||||
| 4. Round | 09/10/2021 | Sporting Canamy | - | Cañoneros FC | 0:2 | |
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| 5. Round | 13/10/2021 | Cañoneros FC | - | Yalmakan FC | 0:1 |  |
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| 7. Round | 23/10/2021 | Cañoneros FC | - | Reboceros de La Piedad | 0:2 | |
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| 8. Round | 30/10/2021 | Deportivo Dongu | - | Cañoneros FC | 1:0 | ||||
| 11. Round | 13/11/2021 | Escorpiones | - | Cañoneros FC | 2:1 | ||||
| 12. Round | 20/11/2021 | Cañoneros FC | - | Cafetaleros de Chiapas | 1:3 | ||||
| 13. Round | 26/11/2021 | CD Zap | - | Cañoneros FC | 6:2 | |
Chile