| 2. Round | 15/09/2010 | Oriente Petrolero | - | Deportes Tolima | 1:0 | ||||
| 2. Round | 22/09/2010 | Deportes Tolima | - | Oriente Petrolero | 2:0 |  |
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| Round of 16 | 30/09/2010 | Banfield | - | Deportes Tolima | 2:0 | ||||
| Round of 16 | 13/10/2010 | Deportes Tolima | - | Banfield | 3:0 | ||||
| Quarter-finals | 04/11/2010 | Deportes Tolima | - | Independiente | 2:2 | ||||
| Quarter-finals | 12/11/2010 | Independiente | - | Deportes Tolima | 0:0 |
Colombia