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| 1st(1st leg) | Defensor Sporting | - | Independiente | 1:0 (0:0) | ||
| 2nd (2nd leg) | Independiente | - | Defensor Sporting | 4:2 (3:1) | ||
| 1st(1st leg): 29/09/2010 01:15 | 2nd (2nd leg): 19/10/2010 23:20 | Winner: Independiente | ||||
| 1st(1st leg) | Banfield | - | Deportes Tolima | 2:0 (2:0) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Banfield | 3:0 (2:0) | ||
| 1st(1st leg): 30/09/2010 01:15 | 2nd (2nd leg): 13/10/2010 02:30 | Winner: Deportes Tolima | ||||
| 1st(1st leg) | Newell's Old Boys | - | San José | 6:0 (3:0) | ||
| 2nd (2nd leg) | San José | - | Newell's Old Boys | 2:0 (1:0) | ||
| 1st(1st leg): 07/10/2010 01:15 | 2nd (2nd leg): 22/10/2010 01:45 | Winner: Newell's Old Boys | ||||
| 1st(1st leg) | Unión San Felipe | - | LDU Quito | 4:2 (2:1) | ||
| 2nd (2nd leg) | LDU Quito | - | Unión San Felipe | 6:1 (2:1) | ||
| 1st(1st leg): 13/10/2010 00:15 | 2nd (2nd leg): 20/10/2010 02:00 | Winner: LDU Quito | ||||
| 1st(1st leg) | Goiás - GO | - | Peñarol | 1:0 (1:0) | ||
| 2nd (2nd leg) | Peñarol | - | Goiás - GO | 3:2 (2:1) | ||
| 1st(1st leg): 13/10/2010 23:30 | 2nd (2nd leg): 20/10/2010 22:30 | Winner: Goiás - GO | ||||
| 1st(1st leg) | Atlético Mineiro | - | Santa Fe | 2:0 (1:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Atlético Mineiro | 1:0 (0:0) | ||
| 1st(1st leg): 14/10/2010 02:00 | 2nd (2nd leg): 21/10/2010 01:00 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Emelec | - | Avaí - SC | 2:1 (0:0) | ||
| 2nd (2nd leg) | Avaí - SC | - | Emelec | 3:1 (0:1) | ||
| 1st(1st leg): 14/10/2010 02:00 | 2nd (2nd leg): 21/10/2010 23:15 | Winner: Avaí - SC | ||||
| 1st(1st leg) | Universitario de Sucre | - | Palmeiras | 0:1 (0:1) | ||
| 2nd (2nd leg) | Palmeiras | - | Universitario de Sucre | 3:1 (2:0) | ||
| 1st(1st leg): 15/10/2010 01:15 | 2nd (2nd leg): 21/10/2010 01:00 | Winner: Palmeiras | ||||
