| 1. Round | 23/01/2010 | River Plate | - | Fénix | 0:1 |  |
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| 3. Round | 06/02/2010 | Rampla Juniors | - | River Plate | 2:1 |  |
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| 5. Round | 19/02/2010 | Nacional | - | River Plate | 1:4 | |
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| 4. Round | 24/02/2010 | River Plate | - | Danubio | 3:0 | |
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| 6. Round | 27/02/2010 | River Plate | - | Peñarol | 2:3 | ||||
| 9. Round | 21/03/2010 | Liverpool | - | River Plate | 1:1 | |
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| 8. Round | 24/03/2010 | River Plate | - | CA Cerro | 0:1 | ||||
| 10. Round | 28/03/2010 | River Plate | - | Cerrito | 3:0 | |
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| 11. Round | 04/04/2010 | River Plate | - | Tacuarembó | 3:1 | |
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| 13. Round | 17/04/2010 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 14. Round | 25/04/2010 | River Plate | - | Racing | 4:1 | |
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| 15. Round | 02/05/2010 | Montevideo Wanderers | - | River Plate | 2:2 | |
Uruguay