| 2. Round | 16/01/2022 | Atlético San Luis [U16] | - | Mazatlán FC [U16] | 1:2 | ||||
| 3. Round | 22/01/2022 | Club Tijuana [U16] | - | Atlético San Luis [U16] | 2:0 | ||||
| 4. Round | 29/01/2022 | Atlético San Luis [U16] | - | Atlas Guadalajara [U16] | 0:1 | ||||
| 9. Round | 05/03/2022 | Atlético San Luis [U16] | - | UANL Tigres [U16] | 1:1 | ||||
| 10. Round | 12/03/2022 | Atlético San Luis [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 12. Round | 26/03/2022 | Atlético San Luis [U16] | - | CF Monterrey [U16] | 1:1 |  |
Mexico