| 1. Round | 07/02/2025 | Cavalry FC | - | Pumas UNAM | 2:1 | ||||
| 1. Round | 14/02/2025 | Pumas UNAM | - | Cavalry FC | 2:0 | ||||
| Round of 16 | 05/03/2025 | Pumas UNAM | - | LD Alajuelense | 2:0 | ||||
| Round of 16 | 14/03/2025 | LD Alajuelense | - | Pumas UNAM | 1:1 | ||||
| Quarter-finals | 03/04/2025 | Vancouver Whitecaps | - | Pumas UNAM | 1:1 |  |
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| Quarter-finals | 10/04/2025 | Pumas UNAM | - | Vancouver Whitecaps | 2:2 | |
USA
Mexico