| 1. Round | 20/03/2021 | Club San José | - | Atlético Palmaflor | 1:3 | ||||
| 4. Round | 10/04/2021 | Atlético Palmaflor | - | Oriente Petrolero | 2:1 | ||||
| 6. Round | 03/05/2021 | Atlético Palmaflor | - | Jorge Wilstermann | 3:1 | ||||
| 8. Round | 11/07/2021 | Always Ready | - | Atlético Palmaflor | 3:2 | ||||
| 14. Round | 08/08/2021 | Club Aurora | - | Atlético Palmaflor | 2:1 | ||||
| 18. Round | 14/09/2021 | Atlético Palmaflor | - | Nacional Potosí | 0:0 | ||||
| 19. Round | 20/09/2021 | Oriente Petrolero | - | Atlético Palmaflor | 3:0 | ||||
| 20. Round | 22/09/2021 | Atlético Palmaflor | - | The Strongest | 0:0 |  |
Bolivia