| 9. Round | 21/09/2016 | Emelec | - | Club Deportivo River Plate Ecuador | 5:0 | ||||
| 10. Round | 25/09/2016 | Club Deportivo River Plate Ecuador | - | Fuerza Amarilla | 2:1 | ||||
| 11. Round | 01/10/2016 | Universidad Catolica | - | Club Deportivo River Plate Ecuador | 2:1 | ||||
| 12. Round | 08/10/2016 | Club Deportivo River Plate Ecuador | - | Universidad Catolica | 3:0 | ||||
| 13. Round | 15/10/2016 | Fuerza Amarilla | - | Club Deportivo River Plate Ecuador | 2:1 | ||||
| 14. Round | 20/10/2016 | Club Deportivo River Plate Ecuador | - | Emelec | 0:2 | ||||
| 15. Round | 23/10/2016 | Barcelona | - | Club Deportivo River Plate Ecuador | 1:0 | ||||
| 18. Round | 13/11/2016 | Aucas | - | Club Deportivo River Plate Ecuador | 3:1 | ||||
| 19. Round | 19/11/2016 | Club Deportivo River Plate Ecuador | - | Deportivo Cuenca | 2:1 | ||||
| 20. Round | 26/11/2016 | LDU Quito | - | Club Deportivo River Plate Ecuador | 1:0 | ||||
| 21. Round | 04/12/2016 | Club Deportivo River Plate Ecuador | - | Delfín SC | 0:1 | ||||
| 22. Round | 10/12/2016 | Independiente del Valle | - | Club Deportivo River Plate Ecuador | 3:2 |  |
Colombia