| 1. Round | 25/08/2010 | River Plate | - | Defensor Sporting | 1:1 |  |
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| 2. Round | 29/08/2010 | Rampla Juniors | - | River Plate | 0:1 | ||||
| 3. Round | 05/09/2010 | River Plate | - | Central Español | 1:3 |  |
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| 4. Round | 18/09/2010 | Racing | - | River Plate | 2:0 |  |
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| 6. Round | 03/10/2010 | Danubio | - | River Plate | 1:2 | ||||
| 7. Round | 09/10/2010 | River Plate | - | Peñarol | 2:1 | ||||
| 9. Round | 24/10/2010 | River Plate | - | Liverpool | 1:2 | ||||
| 10. Round | 30/10/2010 | Nacional | - | River Plate | 6:1 | ||||
| 11. Round | 07/11/2010 | Miramar Misiones | - | River Plate | 1:1 | ||||
| 12. Round | 14/11/2010 | River Plate | - | El Tanque Sisley | 1:2 | ||||
| 13. Round | 21/11/2010 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 14. Round | 27/11/2010 | River Plate | - | Fénix | 1:2 | |
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| 15. Round | 05/12/2010 | Bella Vista | - | River Plate | 1:0 |
Uruguay