3. Round | 07/08/2021 | Mazatlán FC | - | CF Monterrey | 1:1 | ||||
4. Round | 15/08/2021 | Club León | - | Mazatlán FC | 3:0 | ||||
7. Round | 28/08/2021 | Mazatlán FC | - | Atlético San Luis | 2:2 | ||||
8. Round | 12/09/2021 | CF América | - | Mazatlán FC | 2:0 | ||||
9. Round | 19/09/2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | ||||
10. Round | 25/09/2021 | Club Tijuana | - | Mazatlán FC | 0:0 | ||||
11. Round | 29/09/2021 | Mazatlán FC | - | FC Juárez | 3:1 | ||||
12. Round | 03/10/2021 | Santos Laguna | - | Mazatlán FC | 1:0 |