| 1. Round | 01/04/2018 | Rio Grande Valley FC | - | Sacramento Republic | 2:2 |  |
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| 2. Round | 26/04/2018 | Rio Grande Valley FC | - | Orange County SC | 2:0 | ||||
| 4. Round | 05/06/2018 | Real Monarchs SLC | - | Rio Grande Valley FC | 2:0 | |
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| 4. Round | 17/06/2018 | OKC Energy FC | - | Rio Grande Valley FC | 3:1 | ||||
| 4. Round | 01/07/2018 | Saint Louis FC | - | Rio Grande Valley FC | 0:0 | ||||
| 5. Round | 08/07/2018 | Rio Grande Valley FC | - | Tulsa Roughnecks | 1:1 | ||||
| 5. Round | 15/07/2018 | Rio Grande Valley FC | - | Las Vegas Lights FC | 2:0 | ||||
| 5. Round | 29/07/2018 | Rio Grande Valley FC | - | Colorado Springs Switchbacks | 1:0 | ||||
| 6. Round | 12/08/2018 | Sacramento Republic | - | Rio Grande Valley FC | 2:1 | ||||
| 6. Round | 23/08/2018 | Los Angeles Galaxy II | - | Rio Grande Valley FC | 1:1 | ||||
| 6. Round | 26/08/2018 | Orange County SC | - | Rio Grande Valley FC | 0:2 | ||||
| 6. Round | 30/08/2018 | Rio Grande Valley FC | - | San Antonio FC | 1:3 | ||||
| 7. Round | 27/09/2018 | Reno 1868 FC | - | Rio Grande Valley FC | 4:0 | |
Jamaica