| 1. Round | 12/09/2020 | FC Twente | - | Fortuna Sittard | 2:0 | ||||
| 2. Round | 19/09/2020 | Fortuna Sittard | - | sc Heerenveen | 1:3 | ||||
| 3. Round | 26/09/2020 | Fortuna Sittard | - | AZ Alkmaar | 3:3 |  |
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| 4. Round | 04/10/2020 | PSV Eindhoven | - | Fortuna Sittard | 2:0 | ||||
| 5. Round | 18/10/2020 | FC Emmen | - | Fortuna Sittard | 2:2 | ||||
| 6. Round | 25/10/2020 | Fortuna Sittard | - | FC Groningen | 1:3 | ||||
| 7. Round | 31/10/2020 | AFC Ajax | - | Fortuna Sittard | 5:2 | ||||
| 8. Round | 06/11/2020 | Fortuna Sittard | - | PEC Zwolle | 2:2 | ||||
| 9. Round | 22/11/2020 | Fortuna Sittard | - | Feyenoord | 1:3 | ||||
| 10. Round | 29/11/2020 | Vitesse | - | Fortuna Sittard | 2:0 | ||||
| 13. Round | 19/12/2020 | FC Utrecht | - | Fortuna Sittard | 1:1 | ||||
| 15. Round | 10/01/2021 | sc Heerenveen | - | Fortuna Sittard | 1:3 | ||||
| 17. Round | 16/01/2021 | PEC Zwolle | - | Fortuna Sittard | 0:2 | ||||
| 19. Round | 27/01/2021 | RKC Waalwijk | - | Fortuna Sittard | 1:2 | ||||
| 20. Round | 30/01/2021 | Fortuna Sittard | - | VVV-Venlo | 3:2 |
Netherlands