| 1. Round | 05/03/2017 | Orlando City | - | New York City FC | 1:0 | ||||
| 1. Round | 18/03/2017 | Orlando City | - | Philadelphia Union | 2:1 | ||||
| 2. Round | 01/04/2017 | Columbus Crew | - | Orlando City | 2:0 | ||||
| 3. Round | 07/05/2017 | Houston Dynamo | - | Orlando City | 4:0 | ||||
| 3. Round | 14/05/2017 | Orlando City | - | Sporting Kansas City | 2:2 |  |
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| 3. Round | 18/05/2017 | San Jose Earthquakes | - | Orlando City | 1:1 | ||||
| 3. Round | 28/05/2017 | Minnesota United FC | - | Orlando City | 1:0 | ||||
| 3. Round | 01/06/2017 | Orlando City | - | D.C. United | 2:0 | ||||
| 4. Round | 18/06/2017 | Orlando City | - | Impact de Montréal | 3:3 | |
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| 5. Round | 01/07/2017 | Real Salt Lake | - | Orlando City | 0:1 | |
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| 5. Round | 06/07/2017 | Orlando City | - | Toronto FC | 1:3 | |
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| 5. Round | 22/07/2017 | Orlando City | - | Atlanta United FC | 0:1 | ||||
| 5. Round | 29/07/2017 | Atlanta United FC | - | Orlando City | 1:1 | ||||
| 6. Round | 06/08/2017 | Impact de Montréal | - | Orlando City | 2:1 | ||||
| 7. Round | 03/09/2017 | New England Revolution | - | Orlando City | 4:0 |  |
Uruguay