| 1. Round | 11/09/2021 | Sud América | - | Montevideo City Torque | 1:2 | ||||
| 2. Round | 19/09/2021 | Montevideo City Torque | - | Plaza Colonia | 2:2 | ||||
| 4. Round | 03/10/2021 | Montevideo City Torque | - | Boston River | 4:3 | ||||
| 5. Round | 09/10/2021 | Montevideo Wanderers | - | Montevideo City Torque | 0:1 | ||||
| 6. Round | 16/10/2021 | Montevideo City Torque | - | Rentistas | 1:2 | ||||
| 7. Round | 21/10/2021 | Peñarol | - | Montevideo City Torque | 3:1 | ||||
| 8. Round | 24/10/2021 | Deportivo Maldonado | - | Montevideo City Torque | 2:1 |  |
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| 9. Round | 31/10/2021 | Montevideo City Torque | - | Villa Española | 5:0 | ||||
| 10. Round | 04/11/2021 | Nacional | - | Montevideo City Torque | 2:0 | ||||
| 11. Round | 07/11/2021 | Cerrito | - | Montevideo City Torque | 0:2 | ||||
| 12. Round | 13/11/2021 | Liverpool | - | Montevideo City Torque | 1:3 | |
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| 13. Round | 22/11/2021 | Montevideo City Torque | - | River Plate | 1:1 | ||||
| 14. Round | 29/11/2021 | Cerro Largo | - | Montevideo City Torque | 1:1 | ||||
| 15. Round | 04/12/2021 | Montevideo City Torque | - | Progreso | 1:0 |  |
Uruguay