| 1. Round | 01/02/2025 | Defensor Sporting | - | Boston River | 2:0 | ||||
| 2. Round | 08/02/2025 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 3. Round | 16/02/2025 | Defensor Sporting | - | Racing | 2:0 | ||||
| 4. Round | 23/02/2025 | Plaza Colonia | - | Defensor Sporting | 1:2 | ||||
| 5. Round | 07/03/2025 | Defensor Sporting | - | Liverpool | 0:1 | ||||
| 6. Round | 16/03/2025 | Juventud de Las Piedras | - | Defensor Sporting | 2:1 | ||||
| 7. Round | 23/03/2025 | Defensor Sporting | - | Cerro Largo | 0:0 |  |
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| 8. Round | 27/03/2025 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 9. Round | 01/04/2025 | Defensor Sporting | - | Miramar Misiones | 2:0 | ||||
| 10. Round | 07/04/2025 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | ||||
| 11. Round | 14/04/2025 | Defensor Sporting | - | CA Cerro | 3:2 | ||||
| 12. Round | 20/04/2025 | Defensor Sporting | - | Progreso | 1:2 | ||||
| 13. Round | 27/04/2025 | Montevideo City Torque | - | Defensor Sporting | 0:1 |
Uruguay