| 2. Round | 15/01/2022 | Deportivo Toluca [U16] | - | Club Necaxa [U16] | 7:1 | ||||
| 3. Round | 22/01/2022 | Gallos Blancos [U16] | - | Deportivo Toluca [U16] | 2:2 | ||||
| 4. Round | 29/01/2022 | Deportivo Toluca [U16] | - | Pumas UNAM [U16] | 2:0 | ||||
| 6. Round | 12/02/2022 | Puebla FC [U16] | - | Deportivo Toluca [U16] | 1:2 | ||||
| 1. Round | 15/02/2022 | FC Juárez [U16] | - | Deportivo Toluca [U16] | 3:1 | ||||
| 8. Round | 26/02/2022 | CF América [U16] | - | Deportivo Toluca [U16] | 0:4 | ||||
| 9. Round | 05/03/2022 | Deportivo Toluca [U16] | - | CF Pachuca [U16] | 1:1 | ||||
| 10. Round | 12/03/2022 | Deportivo Toluca [U16] | - | Puebla FC [U16] | 3:4 | ||||
| 11. Round | 19/03/2022 | Club Necaxa [U16] | - | Deportivo Toluca [U16] | 1:0 | ||||
| 13. Round | 02/04/2022 | Cruz Azul [U16] | - | Deportivo Toluca [U16] | 0:1 |  |
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| 14. Round | 10/04/2022 | Deportivo Toluca [U16] | - | FC Juárez [U16] | 7:0 | ||||
| 15. Round | 16/04/2022 | Deportivo Toluca [U16] | - | CF América [U16] | 1:2 | ||||
| 16. Round | 23/04/2022 | Pumas UNAM [U16] | - | Deportivo Toluca [U16] | 3:4 | |
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| 17. Round | 30/04/2022 | CF Pachuca [U16] | - | Deportivo Toluca [U16] | 0:0 |
Mexico