| 2. Round | 02/07/2022 | Deportivo Toluca [U16] | - | Club Necaxa [U16] | 4:4 |  |
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| 3. Round | 09/07/2022 | Pumas UNAM [U16] | - | Deportivo Toluca [U16] | 2:1 | ||||
| 4. Round | 16/07/2022 | Deportivo Toluca [U16] | - | CF Pachuca [U16] | 3:0 | |
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| 5. Round | 23/07/2022 | FC Juárez [U16] | - | Deportivo Toluca [U16] | 0:4 | |
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| 6. Round | 30/07/2022 | Deportivo Toluca [U16] | - | CF América [U16] | 2:5 | |
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| 7. Round | 06/08/2022 | Puebla FC [U16] | - | Deportivo Toluca [U16] | 4:2 | ||||
| 8. Round | 13/08/2022 | Deportivo Toluca [U16] | - | Cruz Azul [U16] | 3:3 | ||||
| 11. Round | 03/09/2022 | Club Necaxa [U16] | - | Deportivo Toluca [U16] | 3:2 | |
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| 9. Round | 07/09/2022 | Gallos Blancos [U16] | - | Deportivo Toluca [U16] | 1:3 | ||||
| 12. Round | 10/09/2022 | Deportivo Toluca [U16] | - | Pumas UNAM [U16] | 2:1 | |
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| 13. Round | 17/09/2022 | CF Pachuca [U16] | - | Deportivo Toluca [U16] | 1:2 | ||||
| 14. Round | 24/09/2022 | Deportivo Toluca [U16] | - | FC Juárez [U16] | 3:0 | ||||
| 15. Round | 01/10/2022 | CF América [U16] | - | Deportivo Toluca [U16] | 0:4 | |
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| 16. Round | 08/10/2022 | Deportivo Toluca [U16] | - | Puebla FC [U16] | 3:1 | |
Mexico