| 4. Round | 12/04/2021 | Real Potosí | - | Club San José | 3:0 | ||||
| 5. Round | 24/04/2021 | Club San José | - | CD Guabirá | 0:1 | ||||
| 6. Round | 04/05/2021 | Blooming | - | Club San José | 4:0 | ||||
| 8. Round | 10/07/2021 | Club Aurora | - | Club San José | 3:0 |  |
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| 11. Round | 26/07/2021 | Real Santa Cruz | - | Club San José | 5:0 | ||||
| 12. Round | 30/07/2021 | Club San José | - | Nacional Potosí | 0:4 | ||||
| 13. Round | 04/08/2021 | Oriente Petrolero | - | Club San José | 4:0 | ||||
| 14. Round | 07/08/2021 | Club San José | - | The Strongest | 0:1 | ||||
| 15. Round | 15/08/2021 | Jorge Wilstermann | - | Club San José | 4:0 | |
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| 17. Round | 21/08/2021 | Club San José | - | Always Ready | 0:4 | ||||
| 19. Round | 17/09/2021 | Club San José | - | Real Potosí | 0:0 | ||||
| 22. Round | 20/10/2021 | Bolívar | - | Club San José | 4:1 | ||||
| 25. Round | 01/11/2021 | Independiente Petrolero | - | Club San José | 4:0 | ||||
| 29. Round | 05/12/2021 | The Strongest | - | Club San José | 2:0 |
Bolivia