| 6. Round | 20/02/2022 | CD Zap | - | Montañeses FC | 0:1 | ||||
| 9. Round | 13/03/2022 | Yalmakan FC | - | CD Zap | 1:1 | ||||
| 8. Round | 24/03/2022 | CD Zap | - | Sporting Canamy | 2:1 |  |
|||
| 2. Round | 30/03/2022 | Escorpiones | - | CD Zap | 1:0 | ||||
| 12. Round | 03/04/2022 | CD Zap | - | Deportivo Dongu | 2:1 | ||||
| 13. Round | 09/04/2022 | Cañoneros FC | - | CD Zap | 3:2 |
Mexico