| Zona B | 31/03/2021 | Cobán Imperial | - | Achuapa | 3:2 | ||||
| Zona B | 04/04/2021 | Sacachispas | - | Cobán Imperial | 1:2 | ||||
| Zona B | 07/04/2021 | Sanarate | - | Cobán Imperial | 0:0 | ||||
| Zona B | 10/04/2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | ||||
| Interzone | 14/04/2021 | Cobán Imperial | - | Iztapa | 2:2 | ||||
| Interzone | 17/04/2021 | Santa Lucía | - | Cobán Imperial | 1:1 | ||||
| Interzone | 21/04/2021 | Cobán Imperial | - | Xelaju MC | 0:0 | ||||
| Interzone | 25/04/2021 | Deportivo Malacateco | - | Cobán Imperial | 0:0 | ||||
| Interzone | 02/05/2021 | Comunicaciones | - | Cobán Imperial | 1:1 | ||||
| Quarter-finals | 06/05/2021 | Cobán Imperial | - | Santa Lucía | 1:1 | ||||
| Quarter-finals | 09/05/2021 | Santa Lucía | - | Cobán Imperial | 3:0 |
Panama