| 1. Round | 22/01/2019 | Sol de América | - | Libertad | 2:0 | ||||
| 2. Round | 27/01/2019 | Libertad | - | Cerro Porteño | 1:0 | ||||
| 5. Round | 09/02/2019 | Libertad | - | General Díaz | 4:0 | ||||
| 6. Round | 16/02/2019 | River Plate | - | Libertad | 1:1 | ||||
| 7. Round | 24/02/2019 | Libertad | - | Club Olimpia | 2:3 | ||||
| 9. Round | 03/03/2019 | Libertad | - | San Lorenzo | 2:1 | ||||
| 10. Round | 09/03/2019 | Sportivo Luqueño | - | Libertad | 2:2 | ||||
| 11. Round | 16/03/2019 | Libertad | - | Deportivo Santaní | 4:0 | ||||
| 4. Round | 20/03/2019 | Deportivo Capiatá | - | Libertad | 2:1 | ||||
| 8. Round | 27/03/2019 | Club Nacional | - | Libertad | 0:1 | ||||
| 15. Round | 08/04/2019 | Libertad | - | Deportivo Capiatá | 5:1 |  |
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| 17. Round | 21/04/2019 | Libertad | - | River Plate | 2:1 | ||||
| 18. Round | 28/04/2019 | Club Olimpia | - | Libertad | 3:0 | ||||
| 20. Round | 06/05/2019 | San Lorenzo | - | Libertad | 3:4 | |
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| 21. Round | 12/05/2019 | Libertad | - | Sportivo Luqueño | 1:0 | ||||
| 22. Round | 17/05/2019 | Deportivo Santaní | - | Libertad | 0:3 |
Paraguay