| 4. Round | 27/02/2022 | Tacuary | - | Libertad | 0:1 | ||||
| 5. Round | 06/03/2022 | Libertad | - | Sportivo Ameliano | 2:0 | ||||
| 9. Round | 10/04/2022 | Libertad | - | Sol de América | 3:1 | ||||
| 10. Round | 17/04/2022 | Cerro Porteño | - | Libertad | 4:0 | ||||
| 17. Round | 23/05/2022 | Libertad | - | Club Nacional | 1:0 | ||||
| 22. Round | 03/07/2022 | Resistencia SC | - | Libertad | 0:4 |
Paraguay