| 5. Round | 31/08/2020 | Santa Cruz | - | Deportes Melipilla | 2:4 | ||||
| 6. Round | 05/09/2020 | Deportes Melipilla | - | Unión San Felipe | 0:1 | ||||
| 10. Round | 22/09/2020 | Barnechea | - | Deportes Melipilla | 0:1 |  |
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| 11. Round | 27/09/2020 | Deportes Melipilla | - | Ñublense | 1:0 | ||||
| 12. Round | 01/10/2020 | CD Magallanes | - | Deportes Melipilla | 0:0 | ||||
| 13. Round | 05/10/2020 | Deportes Melipilla | - | Santiago Morning | 1:1 | |
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| 14. Round | 08/10/2020 | Deportes Melipilla | - | Puerto Montt | 2:0 | |
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| 15. Round | 12/10/2020 | Deportes Temuco | - | Deportes Melipilla | 0:3 | ||||
| 16. Round | 28/10/2020 | Deportes Melipilla | - | Deportes Copiapó | 1:2 | ||||
| 17. Round | 04/11/2020 | Ñublense | - | Deportes Melipilla | 4:0 | |
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| 18. Round | 08/11/2020 | Deportes Melipilla | - | San Luis | 3:0 | |
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| 19. Round | 12/11/2020 | Puerto Montt | - | Deportes Melipilla | 0:0 | ||||
| 20. Round | 17/11/2020 | Deportes Melipilla | - | CD Magallanes | 0:0 | ||||
| 28. Round | 30/12/2020 | Cobreloa | - | Deportes Melipilla | 0:0 |  |
Chile