| 6. Round | 16/10/2021 | Leviatán FC | - | Cafetaleros de Chiapas | 0:7 | ||||
| 7. Round | 22/10/2021 | CD Zap | - | Leviatán FC | 3:0 | ||||
| 8. Round | 01/11/2021 | Leviatán FC | - | Inter de Querétaro | 0:3 | ||||
| 9. Round | 07/11/2021 | Montañeses FC | - | Leviatán FC | 0:1 | ||||
| 10. Round | 10/11/2021 | Leviatán FC | - | Inter Playa | 0:5 |
Mexico