| 3. Round | 09/07/2022 | UANL Tigres [U16] | - | Deportivo Guadalajara [U16] | 1:3 | ||||
| 2. Round | 13/07/2022 | Club León [U16] | - | UANL Tigres [U16] | 0:1 | ||||
| 4. Round | 16/07/2022 | Club Tijuana [U16] | - | UANL Tigres [U16] | 2:0 | ||||
| 5. Round | 23/07/2022 | UANL Tigres [U16] | - | CF Monterrey [U16] | 0:2 | ||||
| 6. Round | 30/07/2022 | Atlético San Luis [U16] | - | UANL Tigres [U16] | 2:5 | ||||
| 7. Round | 06/08/2022 | UANL Tigres [U16] | - | Mazatlán FC [U16] | 0:1 | ||||
| 8. Round | 13/08/2022 | Santos Laguna [U16] | - | UANL Tigres [U16] | 1:0 | ||||
| 11. Round | 03/09/2022 | Atlas Guadalajara [U16] | - | UANL Tigres [U16] | 2:0 |  |
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| 12. Round | 10/09/2022 | UANL Tigres [U16] | - | Santos Laguna [U16] | 2:1 |  |
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| 13. Round | 17/09/2022 | Mazatlán FC [U16] | - | UANL Tigres [U16] | 1:2 | ||||
| 15. Round | 01/10/2022 | CF Monterrey [U16] | - | UANL Tigres [U16] | 1:3 | ||||
| 16. Round | 08/10/2022 | UANL Tigres [U16] | - | Club Tijuana [U16] | 4:1 | |
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| 17. Round | 15/10/2022 | Deportivo Guadalajara [U16] | - | UANL Tigres [U16] | 3:1 | ||||
| 18. Round | 22/10/2022 | UANL Tigres [U16] | - | Club León [U16] | 1:1 |
Mexico