| 1. Round | 19/02/2022 | Emelec | - | Macará | 4:0 | ||||
| 2. Round | 28/02/2022 | Independiente del Valle | - | Emelec | 0:1 | ||||
| 3. Round | 05/03/2022 | Emelec | - | Guayaquil City | 2:2 | ||||
| 4. Round | 14/03/2022 | Gualaceo SC | - | Emelec | 2:1 | ||||
| 7. Round | 10/04/2022 | Deportivo Cuenca | - | Emelec | 2:2 |  |
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| 8. Round | 17/04/2022 | Emelec | - | 9 de Octubre | 2:1 | |
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| 9. Round | 22/04/2022 | Cumbayá | - | Emelec | 1:1 |  |
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| 10. Round | 24/04/2022 | Emelec | - | Aucas | 1:0 | ||||
| 12. Round | 08/05/2022 | Emelec | - | Mushuc Runa | 4:0 | |
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| 11. Round | 12/05/2022 | Barcelona | - | Emelec | 1:1 | ||||
| 13. Round | 15/05/2022 | Orense SC | - | Emelec | 2:0 | ||||
| 14. Round | 21/05/2022 | Emelec | - | Universidad Catolica | 0:1 |
Ecuador