| 1. Round | 19/09/2021 | Lobos ULMX | - | Sporting Canamy | 0:0 | ||||
| 2. Round | 25/09/2021 | Sporting Canamy | - | Reboceros de La Piedad | 0:3 | ||||
| 3. Round | 02/10/2021 | Deportivo Dongu | - | Sporting Canamy | 1:2 |  |
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| 4. Round | 09/10/2021 | Sporting Canamy | - | Cañoneros FC | 0:2 | ||||
| 6. Round | 16/10/2021 | Sporting Canamy | - | Escorpiones | 2:1 | ||||
| 7. Round | 25/10/2021 | Cafetaleros de Chiapas | - | Sporting Canamy | 1:1 | ||||
| 8. Round | 30/10/2021 | Sporting Canamy | - | CD Zap | 0:1 | |
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| 9. Round | 06/11/2021 | Inter de Querétaro | - | Sporting Canamy | 1:0 | ||||
| 10. Round | 10/11/2021 | Sporting Canamy | - | Montañeses FC | 2:1 | ||||
| 11. Round | 13/11/2021 | Leviatán FC | - | Sporting Canamy | 0:3 dec. | ||||
| 12. Round | 19/11/2021 | Inter Playa | - | Sporting Canamy | 7:1 |
Mexico