| 1. Round | 03/04/2022 | Unión Comercio | - | Cusco FC | 1:0 | ||||
| 3. Round | 16/04/2022 | Cusco FC | - | Alfonso Ugarte | 2:2 | ||||
| 4. Round | 24/04/2022 | Chavelines Juniors | - | Cusco FC | 0:1 | ||||
| 7. Round | 15/05/2022 | Cusco FC | - | Los Chankas | 2:1 | ||||
| 8. Round | 22/05/2022 | Santos FC | - | Cusco FC | 1:2 |  |
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| 9. Round | 28/05/2022 | Cusco FC | - | Deportivo Coopsol | 3:0 | |
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| 10. Round | 05/06/2022 | Unión Huaral | - | Cusco FC | 0:1 | |
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| 11. Round | 11/06/2022 | Cusco FC | - | Juan Aurich | 2:0 | |
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| 12. Round | 19/06/2022 | Alianza Universidad | - | Cusco FC | 0:2 | ||||
| 13. Round | 26/06/2022 | Cusco FC | - | Comerciantes Unidos | 3:2 | |
Panama