| 1. Round | 25/07/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 2. Round | 01/08/2021 | CF Monterrey | - | Pumas UNAM | 2:0 | ||||
| 3. Round | 08/08/2021 | Pumas UNAM | - | Atlético San Luis | 1:3 |  |
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| 4. Round | 14/08/2021 | Pumas UNAM | - | Gallos Blancos | 0:0 | |
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| 14. Round | 21/10/2021 | Club León | - | Pumas UNAM | 1:2 | |
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| 17. Round | 07/11/2021 | Pumas UNAM | - | Cruz Azul | 4:3 |
Mexico