| 1. Round | 03/07/2022 | Pumas UNAM | - | Club Tijuana | 1:1 | ||||
| 2. Round | 10/07/2022 | Club León | - | Pumas UNAM | 3:3 |  |
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| 3. Round | 17/07/2022 | Pumas UNAM | - | Club Necaxa | 1:0 | ||||
| 4. Round | 25/07/2022 | CF Pachuca | - | Pumas UNAM | 0:0 | ||||
| 9. Round | 19/08/2022 | Atlético San Luis | - | Pumas UNAM | 3:2 | ||||
| 10. Round | 21/08/2022 | Pumas UNAM | - | Santos Laguna | 1:5 | ||||
| 16. Round | 25/08/2022 | Pumas UNAM | - | UANL Tigres | 1:1 |
Mexico