| 3. Round | 19/05/2019 | San Antonio FC | - | Tulsa Roughnecks | 1:1 | ||||
| 3. Round | 26/05/2019 | Rio Grande Valley FC | - | San Antonio FC | 3:1 | ||||
| 4. Round | 09/06/2019 | San Antonio FC | - | Reno 1868 FC | 3:2 |  |
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| 4. Round | 16/06/2019 | OKC Energy FC | - | San Antonio FC | 1:1 | ||||
| 4. Round | 22/06/2019 | Fresno FC | - | San Antonio FC | 3:2 | ||||
| 4. Round | 27/06/2019 | San Antonio FC | - | El Paso Locomotive | 0:0 | ||||
| 5. Round | 04/07/2019 | San Antonio FC | - | Austin Bold | 3:0 |  |
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| 5. Round | 21/07/2019 | Orange County SC | - | San Antonio FC | 0:0 | ||||
| 5. Round | 28/07/2019 | San Antonio FC | - | Real Monarchs SLC | 3:1 | ||||
| 6. Round | 04/08/2019 | San Antonio FC | - | Sacramento Republic | 2:3 | ||||
| 6. Round | 11/08/2019 | Reno 1868 FC | - | San Antonio FC | 1:4 | ||||
| 8. Round | 06/10/2019 | Las Vegas Lights FC | - | San Antonio FC | 4:2 | ||||
| 8. Round | 12/10/2019 | Portland Timbers 2 | - | San Antonio FC | 3:4 | ||||
| 8. Round | 20/10/2019 | San Antonio FC | - | Colorado Springs Switchbacks | 2:2 |
USA
Mexico