| 1. Round | 01/08/2003 | Club Necaxa | - | Real San Luis | 1:1 |  |
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| 2. Round | 08/08/2003 | Real San Luis | - | Puebla FC | 4:0 | |
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| 3. Round | 16/08/2003 | Pumas UNAM | - | Real San Luis | 0:0 | ||||
| 4. Round | 22/08/2003 | Real San Luis | - | Cruz Azul | 0:0 | ||||
| 5. Round | 29/08/2003 | Veracruz (old) | - | Real San Luis | 3:1 | ||||
| 6. Round | 05/09/2003 | Real San Luis | - | UAG Tecos | 1:3 | ||||
| 7. Round | 12/09/2003 | CF Monterrey | - | Real San Luis | 3:2 |  |
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| 9. Round | 23/09/2003 | Atlas Guadalajara | - | Real San Luis | 4:1 | ||||
| 10. Round | 26/09/2003 | Real San Luis | - | Club Irapuato | 0:0 | ||||
| 11. Round | 03/10/2003 | Real San Luis | - | Santos Laguna | 3:0 |  |
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| 12. Round | 11/10/2003 | Atlante | - | Real San Luis | 2:0 | ||||
| 13. Round | 17/10/2003 | Real San Luis | - | Jaguares Chiapas | 1:2 | |
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| 14. Round | 21/10/2003 | CF Pachuca | - | Real San Luis | 2:0 | ||||
| 15. Round | 24/10/2003 | Real San Luis | - | Monarcas Morelia | 0:1 | ||||
| 16. Round | 01/11/2003 | Gallos Blancos (old) | - | Real San Luis | 4:4 | |
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| 17. Round | 07/11/2003 | Real San Luis | - | UANL Tigres | 0:2 | ||||
| 18. Round | 10/11/2003 | Deportivo Toluca | - | Real San Luis | 5:0 | ||||
| 19. Round | 21/11/2003 | Real San Luis | - | Deportivo Guadalajara | 1:2 |
Uruguay