| 10. Round | 12/03/2022 | FC Juárez | - | Atlas Guadalajara | 1:2 |  |
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| 5. Round | 16/03/2022 | CF Monterrey | - | FC Juárez | 3:0 | |
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| 12. Round | 03/04/2022 | FC Juárez | - | Pumas UNAM | 0:1 | |
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| 13. Round | 10/04/2022 | CF América | - | FC Juárez | 3:0 | |
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| 14. Round | 16/04/2022 | FC Juárez | - | CF Pachuca | 1:2 | ||||
| 15. Round | 20/04/2022 | Deportivo Toluca | - | FC Juárez | 0:1 | ||||
| 16. Round | 23/04/2022 | FC Juárez | - | Mazatlán FC | 0:2 |
Mexico