| 2. Round | 10/07/2022 | Deportivo Guadalajara | - | Atlético San Luis | 0:1 | ||||
| 3. Round | 17/07/2022 | Santos Laguna | - | Deportivo Guadalajara | 1:1 |  |
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| 4. Round | 21/07/2022 | Deportivo Guadalajara | - | Club León | 0:0 |  |
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| 5. Round | 28/07/2022 | Gallos Blancos | - | Deportivo Guadalajara | 2:2 | ||||
| 11. Round | 28/08/2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
| 17. Round | 02/10/2022 | Cruz Azul | - | Deportivo Guadalajara | 2:1 |
Mexico