| 2. Round | 17/01/2021 | Pumas UNAM [U17] | - | Mazatlán FC [U17] | 3:1 | ||||
| 3. Round | 24/01/2021 | Gallos Blancos [U17] | - | Pumas UNAM [U17] | 1:0 | ||||
| 4. Round | 30/01/2021 | Pumas UNAM [U17] | - | Atlas Guadalajara [U17] | 0:0 |  |
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| 6. Round | 14/02/2021 | Deportivo Toluca [U17] | - | Pumas UNAM [U17] | 1:2 | ||||
| 9. Round | 04/03/2021 | Pumas UNAM [U17] | - | Santos Laguna [U17] | 2:1 |  |
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| 10. Round | 07/03/2021 | Pumas UNAM [U17] | - | Cruz Azul [U17] | 2:1 |  |
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| 11. Round | 12/03/2021 | FC Juárez [U17] | - | Pumas UNAM [U17] | 1:1 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis [U17] | - | Pumas UNAM [U17] | 0:3 | ||||
| 13. Round | 04/04/2021 | Pumas UNAM [U17] | - | CF Pachuca [U17] | 5:3 | |
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| 14. Round | 09/04/2021 | Club Necaxa [U17] | - | Pumas UNAM [U17] | 3:0 | |
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| 15. Round | 18/04/2021 | Pumas UNAM [U17] | - | UANL Tigres [U17] | 4:0 | |
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| 16. Round | 23/04/2021 | Puebla FC [U17] | - | Pumas UNAM [U17] | 2:8 | |
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| 17. Round | 01/05/2021 | Pumas UNAM [U17] | - | CF América [U17] | 8:2 |
Mexico