| 3. Round | 21/01/2012 | Monarcas Morelia | - | Club San Luis | 2:0 | ||||
| 6. Round | 12/02/2012 | Club San Luis | - | UANL Tigres | 0:2 | ||||
| 7. Round | 19/02/2012 | Deportivo Guadalajara | - | Club San Luis | 0:0 | ||||
| 9. Round | 04/03/2012 | Santos Laguna | - | Club San Luis | 5:2 | ||||
| 10. Round | 11/03/2012 | Club San Luis | - | CF Pachuca | 0:0 | ||||
| 11. Round | 18/03/2012 | Puebla FC | - | Club San Luis | 0:1 | ||||
| 12. Round | 25/03/2012 | Club San Luis | - | Atlante | 2:3 | ||||
| 14. Round | 08/04/2012 | Club San Luis | - | Jaguares Chiapas | 2:3 | ||||
| 15. Round | 14/04/2012 | Gallos Blancos (old) | - | Club San Luis | 2:2 | ||||
| 16. Round | 21/04/2012 | Club San Luis | - | Club Tijuana | 0:1 |
Mexico