| 1. Round | 21/08/2020 | Cancún FC | - | TM Fútbol Club | 1:0 | ||||
| 2. Round | 28/08/2020 | Cimarrones de Sonora | - | Cancún FC | 2:1 | ||||
| 3. Round | 02/09/2020 | Cancún FC | - | Correcaminos UAT | 2:0 | ||||
| 4. Round | 11/09/2020 | Atlético Morelia | - | Cancún FC | 2:3 |  |
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| 5. Round | 16/09/2020 | Cancún FC | - | Mineros de Zacatecas | 1:1 | ||||
| 6. Round | 23/09/2020 | Dorados de Sinaloa | - | Cancún FC | 1:1 | ||||
| 7. Round | 30/09/2020 | Cancún FC | - | Venados FC | 1:2 | ||||
| 8. Round | 06/10/2020 | Atlante | - | Cancún FC | 2:1 |  |
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| 10. Round | 14/10/2020 | Tapatío | - | Cancún FC | 0:0 | ||||
| 9. Round | 18/10/2020 | Cancún FC | - | Pumas Tabasco | 4:0 | |
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| 11. Round | 22/10/2020 | Leones Negros | - | Cancún FC | 0:1 | |
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| 12. Round | 02/11/2020 | Cancún FC | - | Coyotes de Tlaxcala | 2:0 | ||||
| 13. Round | 05/11/2020 | Tepatitlán | - | Cancún FC | 0:1 | |
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| 14. Round | 12/11/2020 | Cancún FC | - | Alebrijes de Oaxaca | 0:2 | |
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| 15. Round | 19/11/2020 | Cancún FC | - | Club Celaya | 0:2 |  |
Mexico