1. Round | 25/07/2021 | Deportivo Guadalajara | - | Atlético San Luis | 1:2 | ||||
2. Round | 03/08/2021 | Atlético San Luis | - | Gallos Blancos | 1:1 | ||||
8. Round | 11/09/2021 | Puebla FC | - | Atlético San Luis | 2:2 | ||||
14. Round | 22/09/2021 | FC Juárez | - | Atlético San Luis | 1:0 | ||||
13. Round | 17/10/2021 | Atlético San Luis | - | CF América | 0:1 | ||||
16. Round | 01/11/2021 | Atlético San Luis | - | CF Monterrey | 1:1 | ||||
5. Round | 04/11/2021 | CF Pachuca | - | Atlético San Luis | 0:0 | ||||
17. Round | 08/11/2021 | Santos Laguna | - | Atlético San Luis | 0:0 |